Hyperglycosylated hCG activates LH/hCG-receptor with lower activity than hCG
نویسندگان
چکیده
منابع مشابه
Hyperglycosylated hCG.
Hyperglycosylated hCG (hCG-H) is a glycosylation variant of the hormone hCG. Here we review all that is known about this independently functioning molecule. As discussed, it is a very different molecule to the hormone hCG. First, hCG-H is produced by cytotrophoblast cells while regular hCG is made in syncytiotrophoblast cell. Second, it is an autocrine acting directly on the cells which produce...
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Purpose: Trophoblastic cancers (Choriocarcinoma, testicular and ovarian germ cell malignancies) secrete hyperglycosylated hCG and non-trophoblastic cancers secrete hyperglycosylated hCG free βsubunit.Both are structural variants of hCG independent to the hormone hCG. They are autocrines acting on a transforming growth factor β-II (TGF-β-II), receptor not acting on the hormone receptor. Here the...
متن کاملhCG and hyperglycosylated hCG in the establishment and evolution of hemochorial placentation.
The evolution of regular chorionic gonadotropin (CG) and hyperglycosylated CG are linked with the evolution of hemochorial placentation in primates. Recent research with humans shows that regular CG promotes spiral artery angiogenesis and hyperglycosylated CG controls invasion by implanting trophoblast cells. It is inferred that the evolution of regular CG and hyperglycosylated CG in early simi...
متن کاملHuman chorionic gonadotropin (hCG) and hyperglycosylated hCG, seven semi-independent critical molecules: A review
hCG exists in two analogous structures, as typified by the hormone hCG which binds an LH/hCG hormone receptor and the TGFß receptor binding autocrine hyperglycosylated hCG. Both share a common α-subunit and ß-subunit amino acid sequence. From the common hormone hCG and autocrine hyperglycosylated hCG structures there are seven common hCG variants with wildly varying hormone hCG or autocrine hyp...
متن کاملInteraction of human chorionic gonadotropin (hCG) and asialo-hCG with recombinant human thyrotropin receptor.
hCG is a putative thyroid stimulator. The present studies were undertaken to examine its interaction and that of its desialylated variant asialo-hCG with recombinant human TSH (hTSH) receptor (hTSHr). To this end, we transfected a human thyroid carcinoma cell line (HTC) lacking endogenous TSHr with the full-length cDNA of the hTSHr. Unlike the wild type, the transfected cells, termed HTC-TSHr c...
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ژورنال
عنوان ژورنال: Molecular and Cellular Endocrinology
سال: 2019
ISSN: 0303-7207
DOI: 10.1016/j.mce.2018.09.006